Decipher the Natural Code: Why the Bad Weather Can Wrought Death among People

--解码自然：为什么坏的天气是如此危险

Yong Tan

25 October, 2024

Preface: In Chinese Traditional Medicine (CTM), the damp looks like a ferocious monster that can relentlessly bring you with conditions or aggravate at any time; which involved treatment of in applying CTM herb banishing “damp” is commonly the chief prevention to secure your health. As in Western culture, a wet weekend likely transmits a bad emotion because you feel uncomfortable or malaise. From medical statistics on demography, the clamminess weather is revealed responsible to wrought a peak of death burden far away beyond the malaise; and appalling is the cause why does so is unknown until now. On the other hand, some protocols applied show themselves available to reduce the death burden of specific condition. The mainstream upon this subject most often is entangled with multi supposed causes. And, the pattern of study underlies the etiological exploration basically follows a very route, concentrating on that: The pathogens invade the endothelium through certain portal further to reach the target organs to develop a lesion. The ensuing progress of condition should be the topic impairment aggravates to lead organs into failure. In this prose, we offer a hypothesis that is about of an overlapping impairment done with Upper Respiratory Infection (URI) and bad weather that elicits nerve system failure than can present in a systemic comorbidity.

序言：中国传统医学非常重视“湿气”这个病理概念，因为可观察到湿气能导致人群患病或死亡率提升。因此祛湿是非常重要的医疗步骤。西方文化中，潮湿同样代表了身体不适或不舒服。但在医学统计的流行病调查中，揭示湿冷的天气往往出现死亡的高峰远远不是全身难受这么简单。更可怕的是个中原因却是众说纷纭。那么研究工作的基调基本是怀疑病原体通过某个门户入侵到血管，再通过循环系统到达目标脏器形成病灶，再进一步发展导致器官衰竭。本文我们将探讨另一种可能：天气原因与上呼吸道感染（上感）共同作用于中枢神经系统，导引了一个全身的并发症。

Keyword: Bad Weather, Death Burden, Upper Respiratory Infection, Static Electricity, Mucus, Ruan YuHua Syndrome.

关键词：坏天气，死亡率，上呼吸道感染，静电，鼻涕，阮玉华综合征

We commence with a heartbroken number that a study on the correlation about mortality and humidity-temperature with more than 120,000 cases of gone in cardiovascular disease in 11 cities in Zhejiang province, China; the peak of mortality burden is 31.36% in the condition of high humidity and low temperature; moreover, 16.74% is significant for low temperature and humidity. The person for male or youth or with a low level of education or living in coastal region is holding a high risk [1]. This survey conforms with the CTM doctrine of keeping off damp.

我们以一组令人心碎的数字说起，它关于死亡率与湿冷天气相关；调查报告来自11个城市超过12万例居民（罹患心血管疾病）死亡，地点浙江。31.36%的峰值来自高湿低温天气，16.74%只来自冷天气低湿度。当中以男性或年轻或低教育水平或沿海居住为高风险。调查的确符合中国传统医学的论点。

Alternatively, to lower temperature season disposed to contract URI of influenza, in Denmark during 9 consecutive such seasons in the period 2007 to 2016 [2], a significant investigation is effectively used to study a cohort of more than 60,000 patients who with hypertension among which, more than 20,000 of follow-up patients gone in all causes, and the significant protocol to reduce the risk of death is flu vaccine inoculated through these dangerous seasons of whom in convention people think so.

再看另一则报告，来自丹麦连续对9个流感季节的追踪，对象是超过6万例高血压病人的随访。通过对其中2万例死亡调查发现接种流感疫苗有助于减低死亡风险。

We now have to suppose a pathogenesis it can cover the three components of URI, humidity, or temperature for which; we import Ruan YuHua Syndrome (RS) as a physiological mechanism underlying our model; down this way, we have to interrogate what happens upon the epithelium in nasal lining.

我们现在可以假设一个病理的致病模式，其中涵盖三个因素：上感、潮湿和寒冷。为此，我们引入阮玉华综合征作为底层运作模式，调查的重点放在在鼻腔中的上皮细胞。

For elaborate this medical model with plain language, we depart from our everyday life.

为更好地说清楚问题，我们从日常生活入手。

While we try to describe something in present of us, we can exert seeing, tasting, smelling, touching, or hearing to feel it. From milieu surrounding us, how do we feel a high humidity and capture available information? That truth is surprised that our nose can function automatically without our voluntary interfering.

当我们面对一个客观事物时，总可以通过视觉、味觉、嗅觉、触觉或听觉去感受它的存在。但我们是怎么感受潮湿并从中获得相应的信息的？真相很惊人：我们的鼻子是能够在我们的不知不觉中做到的。

The mucus plays the role as is a vital function relevant to our surviving; yet, actually, it looks like a shield covering epithelium with its watery gelatine. It can be defined with two layers, the upper one exposes to the nasal lining contacting with ex/inhaling air. Credited to its presenting watery, here called W-layer. This character is often believed good to performing a clearance in nasal lining that is responsible to convey the pathogens or noxious materials that comes from milieus around us towards to nasopharynx. Of course, it also may contact with moisture or solution.

鼻涕从中扮演了重要角色，也是对我们的生存至关重要。实际上它更像一个盾牌或一层明胶覆盖在鼻腔粘膜表面。它可以抽象地分两层：上层面对鼻腔，接触到通过鼻腔呼吸的空气。该层呈现水样的流动，因此我们称W层，这个物理特点很容易理解它的功能是做清洁用--将病原体或有毒物质带到咽喉形成痰液经口腔排出。当然，它也直接接触到空气中的水汽。

The second layer is interest and particular like film that comprises with a multitude of mucin monomer a sort of polymer that can function like umbrella thus further to interweave each other to compose a matrix covering mucosa this also is the outmost of mature epithelium, we briefly called M-layer. It is with this layer that anything including water, as though lingering in W-layer, would be blocked from addressing to access to epithelium.

第二层是非常重要的，特别是它像一层塑料薄膜，由众多长链分子的粘蛋白个体（像把雨伞）共同组成一个矩阵，相互交织保护下面的鼻腔黏膜（也是上皮细胞的最外层），称W层，功能是防止任何物质（包括水分子）接触到鼻腔的上皮细胞。

It can be seen that there is a clearance between M-layer and Mucosa, we call M-layer Membrane Room (MMR); seen that, a closure ecosystem thus be constituted despite there is a transient chance during the new mucin monomer surrogating the existing one, the matters can move into or out of MMR.

可见W层与鼻腔黏膜有一个空隙，我们称MM间距。显然，在这个狭小的空间里同样孕育一个独立的生态环境。只有新的粘蛋白个体替换旧的个体时候，水才能从W层灌进MM间距。

Consequently, in this case, maybe you think MMR is so static that the external milieu via W-layer scarcely to affect. Take an instance as example, while you spray with sweat water into your nasal cavity, you may experience yourself taking an electrical shock in nose with serious soreness, in contrasting to this adverse affection, with the osmotic solution, such as normal saline, you will suffer nothing. What insane is, what produces the electricity before Michael Faraday born?

因此，此种情况下，你会觉得MM间距是如此地静态和封闭，屏蔽了一切来自W层的影响。拿一个例子，当你向鼻腔射出纯水后，你会感到鼻子一阵的酸疼。恭喜你，你体验到了鼻子被电击的感觉；但是喷生理盐水就不会有任何副作用。疯狂吧？问题是哪来的电力？

Obviously, the disparity between two gradients in sprayed solution becomes the key to explain this strange phenomenon, but relevant to the institution of mucin. The first is shape of mucin polymer like bottle brush that confers porous character in use of small size a physical measure to reject something through [3]; where, to every pore, which exterior or interior, there is respective positive ions or negative acid radicals to build static electrical shield. Particularly, these positive ions compose a nebula with positive repulsion thus renders a character with hydrophobic at bottom of W-layer, also is an interface serving interaction from two layers.

在你身上的实验很明显是问题出在喷出的水的盐度差异。解释这个问题要从粘蛋白个体的构造说起。其实粘蛋白个体很像一个刷瓶子的刷子，独特的造型形成多孔的结构过滤掉大分子，将其挡在W层。但这是不够的，还需挡住更小的分子。这就要依靠物理静电产生的排斥力。事实上，粘蛋白个体形成的“筛孔”中是酸根形成的负电荷，而孔外是正离子形成的正电胶体，使得粘蛋白个体虽然整体电荷呈中性，但化学特性是疏水。正电胶体位于W层，形成两层中间的界面，也是两层互动的地方。

While the W-layer diluted by water such as inhaling moisture, the osmolality can transfer positive ions into W-layer thus thin that nebula so that monomer with surplus negative charge and this impact from change on mucin can immediately be transmitted to MMR.

当W层被淡水稀释后，粘蛋白个体的正电胶体变薄，因为渗透压的作用将胶体中的正离子转移到W层。这样造成原本中性的粘蛋白个体变成带负电荷。

To balance such the electrical affection, raising the positive ions concentration in MMR is avoidable—that can elicit epithelium to transfer water inward from MMR and cells thus in swelling and dilated. On contrary, with hyperosmotic solution washing nasal lining it can induce atrophy. So, we can say a Nasal Mucosa Breathing (NMB).

这种改变很快传递到MM间距，除了电击你的鼻黏膜，更重要的是MM间距必须提高正电荷钠离子的浓度平衡粘蛋白个体带负电荷的情况，因此被W层保护的上皮细胞会吸收MM间距的水分而肿胀。相反，高浓度（比如3%的盐水）冲洗鼻腔将导致细胞萎缩。我们称这种现象为鼻腔黏膜呼吸（NMB）。

As though the moisture into our upper respiratory lining may be identified of a slightly irritation, yet such this little change in cell volume can be seen to bring their membrane reach out towards nasal lining on vertical axis rather than towards to each other. This increasing may avail viral egress [4] for dissemination in nasal lining to yield much more topic infection than existence did since MMR compressing means the distance of microvillar growing from membrane for breach the mucin film, meanwhile microvillar stuffed with many viral particles, would be shortened; moreover, swelling with physical force to aid poking coincides.

可知水汽进入鼻腔造成的NMB影响远不如直接喷水。但是不要忽略这点影响，上皮细胞的长时间的肿胀只能使得其表面向鼻腔方向突出。这会促进病毒在鼻腔内的释放。因为病毒从感染宿主细胞逃逸，靠的是细胞新生长的纤毛突出表面伸向鼻腔。病毒藏在纤毛内部随纤毛刺穿粘蛋白保护盾，细胞的肿胀恰好提供一个便利：缩短刺破的距离和物理地增强穿刺的力量。结果是更多的病毒更快地在鼻腔内形成新的病灶。

Well, if consider the hypertension is caused by impairment the URI afflicts on those basal nuclei of Automatic Nervous System (ANS) laying on cranial bottom, especially the vagal nerve which nuclei staying in medulla oblongata and which task is regulating the metabolism on multi organs including the rhyme of heart beating. Then, connect with Ruan YuHua syndrome (RS) that sounds aseptic inflammation on epithelium can transmit more glucose into cranial bottom, all is readily for conclude the high humidity can get more likely to increase the severity of conditions even to lead to organs in failure.

好吧，比如考虑高血压是由上感损伤颅脑基底节所引起，特别是位于延髓的迷走神经核团的损伤，直接影响内脏的代谢活动，甚至包括心跳戒律的控制。那么关联起阮玉华综合征，其证明肿胀的上皮细胞能够促进向基底节直接输送更多的葡萄糖造成神经毒性，可以给出结论：潮湿更容易增加神经衰竭最终导致器官功能出现紊乱而衰竭，病人死亡。

Compared to the damp danger, the low temperature should be disposed more to accelerate viral transmission among people further for exchanging strains one another whose infection would aggravate ANS in malfunction. During this, viral vaccination against URI is good to patients upon reducing their risk of death.

相较潮湿，寒冷的致病机制更侧重于加速病毒在人群中传播和交换品种以形成新的感染加重神经损害。因此出现在流感传播季节接种疫苗减少死亡的案例。

Discussion. RS well-known is as an essential physiological function its glucose-transportation can serve basal nuclei of ANS for the urgent responds by balance glucose supplement in a lower efficiency performed by circulatory system against sharp increasing demand, both coincides; but the gradient of glucose in cerebrospinal fluid is a key parameter for out of normal range it can induce a pathological effect on neurons. Our pathogenesis above-introduced outlines a progress of impairing ANS further leads to them in failure for hyperglycorrhachia. That can be presented with a set of systemic symptoms is most often that we suppose certain external cause in effect to haul organ into failure.

讨论：阮玉华综合征作为一个底层的生理功能用于传输葡萄糖到基底节，自主神经元的集中地解决心血管系统向该部位传输葡萄糖效率低不足以应付紧急情况的问题。但对于基底节的微环境来说，葡萄糖的浓度变得十分微妙，无论高低都会引发脑神经的损害，尤其是高浓度。这种损害可以常被误诊为外界因素介入躯体脏器的结果。

For example, the lingering pain on body likely signals a coming Acute Myocardial Infarction; in this case, maybe, we have a hallucination reach out for medulla oblongata irritated. So, while the pain on body cannot be alleviated by physical treatments, it likely alarms bell due to nerve in failure.

举个例子，游走性疼痛可能预示一个突发心梗的形成。可能疼痛只是一个幻觉由于延髓被刺激，如果相应疼痛表示的部位，不能以物理方法缓解，那么更多地预示着神经遭受损害，可能功能性衰竭。

Reference

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[3] Lai SK, Wang YY, Hanes J. Mucus-penetrating nanoparticles for drug and gene delivery to mucosal tissues. Adv Drug Deliv Rev. 2009; 61(2): 158-71.

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